An Impaired 20s Proteasome Contributes to the Accumulation of Oxidized Proteins in Multiple Sclerosis and Its Animal Model By
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چکیده
OF DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Biomedical Science The University of New Mexico Albuquerque, New Mexico
منابع مشابه
The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome
One hallmark of aging is the accumulation of protein aggregates, promoted by the unfolding of oxidized proteins. Unraveling the mechanism by which oxidized proteins are degraded may provide a basis to delay the early onset of features, such as protein aggregate formation, that contribute to the aging phenotype. In order to prevent aggregation of oxidized proteins, cells recur to the 20S proteas...
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